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While endogenous carriers like extracellular vesicles or biomimetic coatings are designed to minimize immune recognition, the introduction of targeting ligands, synthetic polymers, or residual manufacturing components can provoke unintended inflammatory or foreign body responses, potentially neutralizing the therapeutic effect or causing adverse events

Real-world persistence data will be particularly important to guide efforts for shoring up the chronic market opportunity, e.g., via digital health support programmes, such as the Omada Health-Evernorth partnership [8]

For drug treatments and qPCR analyses, hiPSC-CM were seeded on gelatin- or Matrigel-coated 12-well plates at 500,000 cells/well in medium containing RPMI 1640, B-27 supplement, 10 M ROCK inhibitor and 10% fetal bovine serum