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A role for selenium-dependent GPX1 in SARS-CoV-2 virulence

2025 Elanco or its affiliates Approved by FDA under NADA # 111-798 PA600581X Revised: November 2025 Elanco DroncitTM (praziquantel tablets) 34 Canine Cestocide EACH TABLET CONTAINS: 34 mg praziquantel

(2022) 8:e09725

Replenishing the nutritional status of the host by increasing vital amino acids such as cysteine to enhance GSH levels and selenium to improve selenium deficiency and facilitate selenoprotein (GSH peroxidases, thioredoxin reductases) expression can inhibit oxidative stress, modulating inflammation, suppressing endothelial dysfunction, and protecting vascular cells against apoptosis and calcification (He et al., 2017