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According to the NCCD, the key determinants that define apoptosis as an RCD are its initiation by caspase-8 and caspase-9 and cell death execution by caspase-3, caspase-6, and caspase-7, which occur at the terminal stage when the cells are already committed to die [6, 73]

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Antioxidant capacity is connected to the capability to neutralize superoxide and hydroxyl radicals, which helps prevent free radical that induced retinal pigment epithelium death [288]