Since VTA GABA neurons in the VTA have also been shown to be outwardly projecting, it is also possible that GLP-1Rs are expressed on GABA neurons in the VTA that project to downstream nuclei including the NAc, CeA, prefrontal cortex, lateral hypothalamus, and the lateral habenula 68,69,70
Molecules 18(6):71947238 Chithra S, Jasim B, Sachidanandan P, Jyothis M, Radhakrishnan EK (2014) Piperine production by endophytic fungus Colletotrichum gloeosporioides isolated from Piper nigrum
Regional brain chemical alterations in young children with autism spectrum disorder
A couple of other considerations include gallbladder disease risk, rarely pancreatitis, and then there's a potential for loss of muscle mass with rapid weight reduction