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Microbiome: focus on causation and mechanism

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However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig

Activated resident alveolar macrophages (AM) and alveolar type II epithelial cells (AEC II) release cytokines and chemokines (120), recruiting immune cells from circulation to the lungs, including a substantial number of neutrophils (121)