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GLP-1 Receptor Distribution: **Brain: Hypothalamus, brainstem (appetite, satiety, nausea signaling) GI tract: Slows gastric emptying Heart: Cardioprotective signaling (modest direct effects

However, when initiating treatment with Ozempic in combination with a sulphonylurea or an insulin, blood glucose self-monitoring may become necessary to adjust the dose of the sulphonylurea or the insulin to reduce the risk of hypoglycaemia