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Other significant safety considerations include a history of pancreatitis, acute kidney injury risk, diabetic retinopathy complications in patients with type 2 diabetes, gallbladder disease, hypoglycemia risk in patients using other diabetes medications, and mental health monitoring for mood changes or suicidal ideation

Strategy 3: Structured drug holiday with behavioral bridging

The average time to reach the desired weight and BMI for the six approved patients was 135 days

Yet GLP-1R knockdown in Sim1 neurons did result in a significant reduction in energy expenditure, in contrary to results from whole-body or hypothalamic GLP-1R knockout models