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For the purpose of anti-aging therapy (with no surgical adjunct), I typically place patients on one IV infusion monthly, maybe a few times the first month, and then encourage subcutaneous doses weekly or every two weeks in between

Usually, B12 is absorbed in the stomach with the help of an intrinsic factor protein

Shaffer CL, Good JAD, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M (2016) Peptidomimetic small molecules disrupt type IV secretion system activity in diverse bacterial pathogens

Its a gradual change that can happen even if your diet stays exactly the same, leading to a slow decline in your energy and mental clarity