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These discoveries deepen our understanding of biocatalysis, raising questions about whether other substances within organisms, beyond gene-coded proteins and nucleic acids, contribute to biocatalytic processes

(33) The limited data underscore the need for further research to clarify appropriate dosing, treatment duration, and the potential effects on growth and development in pediatric populations

Physiological melanin hyperpigmentation is the result of increased melanin biosynthesis by melanocytes in the basal cell layer of the oral epithelium, but pathological melanin pigmentation may be the result of increased number of normal melanocytes or atypical melanocytes, of increased melanogenic activity of normal or atypical melanocytes, or of both