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Male rats with PTSD-like behaviors showed elevated p -cresol (a neurotoxic metabolite linked to overgrowth of Ruminococcaceae and Lachnospiraceae ) in prefrontal cortex, leading to dopaminergic dysfunction with increased DA, increased dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), and significantly elevated DA D3 receptor expression compared to controls (Laudani et al., 2023)
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The TOCC obtained using this model was very close to the corresponding stoichiometric value of 100 mg of ascorbic acid/L (9.52 mg/L versus 9.08 mg/L respectively)
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