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Additionally, developing optimal formulations to overcome potential bioavailability challenges, conducting proof-of-concept investigations in human-derived liver cell models, and performing well-designed early-phase clinical trials in patients with MASLD and T2DM will be crucial to validate its therapeutic potential, evaluate its effects on liver histology and metabolic parameters, and determine its integration with existing standard-of-care therapies

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Study selection and data extraction The titles and abstracts of studies identified by the search strategy were independently screened by two reviewers, and irrelevant studies were excluded