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Dihexa-based compounds do not interact with central or peripheral AT1 receptors, are highly target specific, exhibit little interaction with cardiac channel proteins and hepatic CIP isoforms, and reveal no acute toxicity following a 6x effective dose of Dihexa

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While GLP-1 receptor agonists have been shown to influence gut microbiota composition, evidence linking microbiota characteristics to susceptibility to these adverse events remains limited

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