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Employers want consistency and predictability, said Andy Dum, Director of Commercial Pharmacy at Capital Blue Cross

Adverse events were reported in 90% of drug participants and 86% of placebo participants

While topical products can provide localized skin lightening benefits, their ability to induce significant changes in overall skin tone may be limited compared to systemic methods

Statistical Analysis In line with EMA, FDA and PMDA guidelines, a crossover design was chosen to leverage the lower within-participant variability in PK measures and thereby limit the number of participants required for the study [28,29,30]