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Chugai's medicinal chemistry effort identified a series of non-peptide compounds that activated the GLP-1 receptor with nanomolar potency through a previously unrecognized binding pocket

One of the key mechanisms is increased membrane fluidity, which impairs drug penetration and decreases intracellular accumulation, thereby reducing the drugs effectiveness

This improves repeatability

In an extension study named FINE-ONE clinical trial, a phase 3 trial involving adults who had type 1 diabetes, CKD & albuminuria and were receiving an angiotensin-converting-enzyme (ACE) inhibitor or an angiotensin-receptor blocker (ARB), Finerenone resulted in a significantly greater decrease in the urinary albumin-to-creatinine ratio than placebo