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doi: 10.3727/096368909788341289

We propose the development of next-generation iron chelators specifically targeting bone or the regulation of the hepcidin pathway to mitigate iron overload, thereby alleviating osteoporosis associated with ferroptosis and providing novel strategies for treating iron metabolism-related diseases

The effects of GHK and GHK-PEG on malignant cell proliferation was first tested on U937 cells which were plated in 24 well plates and treated with GHK or PEGylated GHK at 10 and 20 nM for 24 hours and cell proliferation was assessed using a hemocytometer and the effect of each treatment was compared between control and treated samples using analysis of variance (ANOVA)