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, day 7, necrosis and dehiscience ( a ), along with prominent ulcerative colitis, present below and up anastomosis ( b )

Antibodies targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death 1 (PD-1) and its ligand [programmed death-ligand 1 (PD-L1)] are the most consolidated options ( Different phase III trials have explored the safety and efficacy of anti-CTLA-4, anti-PD-1, and anti-PD-L1 antibodies as either monotherapy or combination with another immunotherapy antibody, targeted therapy, or chemotherapy

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Dazzled by success stories theyve heard from the media and people in their lives, they may not fully understand the potential risks and side effects