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Hence, the use of combination therapies to target multiple metabolic pathways to suppress tumor growth may be most effective, especially in identifying cases that induce synthetic lethality, where two drugs induce cell death in combination, but not individually

Approximately 80% of patients respond well to chemotherapy during initial treatment, but as the number of recurrences increases, patients transition from being initially chemotherapy-sensitive to chemotherapy-resistant, which is a key factor contributing to treatment failure [8]

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