Although there is restricted exchange between the cytoplasmic and mitochondrial pools of THF molecules, these compartments are metabolically connected by transport of the one-carbon donors (serine, glycine, and formate) across the mitochondrial membranes
[DOI] [PMC free article] [PubMed] [Google Scholar] 484.Piscaer I., van den Ouweland J.M.W., Vermeersch K., Reynaert N.L., Franssen F.M.E., Keene S., Wouters E.F.M., Janssens W., Vermeer C., Janssen R
While dietary composition and dose influence metabolic load and antioxidant availability, meal timing primarily acts as a zeitgeber for peripheral clocks, thereby modulating circadian alignment independently of caloric intake
This ALCAR regime was based on previous work showing behavioural improvements after treatment with ALCAR (Schaevitz et al, 2012