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It was previously available through compounding pharmacies as a bulk drug substance, but the FDA reclassified it as a Category 2 substance, which effectively restricts compounding pharmacies from producing it

it is an endogenous fragment, and one line of thinking holds that it may be liberated from larger proteins for example, during tissue injury when extracellular-matrix proteins such as collagen and SPARC (osteonectin) are proteolytically degraded

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Therefore it is dependent on the continuous administration of the drug