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They exhibited increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy

Evaluation of Acute Toxicity and the Effect of Single Injected Doses of Zerumbone on the Kidney and Liver Functions in Sprague Dawley Rats