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These are some of the most common symptoms: Their breathing or heartbeat grows slow, erratic, or stops altogether Their body goes limp They cant speak They lose consciousness They start choking, vomiting, or frothing at the mouth Their fingernails and lips turn purple or blue Their skin turns purple-blue if they have light skin or gray if they have dark skin, Their skin becomes clammy to the touch Call for help Once you identify an opioid overdose, take action immediately

This prolonged half-life comes from two key structural modifications

10.1126/science.aaz7548 290 ZhuJ.LinF

Thermo-sensitive TRP channels: novel targets for treating chemotherapy-induced peripheral pain