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In addition, betaine can also be synthesized de novo from dietary choline in the mammalian liver and kidney via a two-step enzymatic process in which choline is first oxidized to betaine aldehyde by choline dehydrogenase

Desde 2021, ao en el que el regulador estadounidense (la FDA) aprob los agonistas de GLP-1 para el control crnico del peso en adultos con obesidad o con sobrepeso y al menos una enfermedad asociada al exceso de peso, la demanda de estos frmacos se ha disparado y ha provocado su escasez en Estados Unidos, algo que tambin est ocurriendo ya en Espaa y el resto de Europa