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Daley and colleagues revealed that hyperglycemia triggers Akt2 activation (phosphorylation) in RPE cells, which in turn increases the expression of EMT markers and fibrosis-related proteins via ERK signaling [6]

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Conclusion Administration of GLP-1RAs in patients with T2D achieved multiple clinical and metabolic benefits, nevertheless, cholelithiasis was more frequent among patients with GLP-1RAs that should be addressed frequently

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