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This effect may be linked to its potent ability to sequester free radicals, as well as its ability to down-regulate NF-B, TNF-, and COX-2, while also up-regulating Nrf-2 proteins in renal tissue [31]

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Based on the here-presented biochemical, structural and computational evidence, we propose that arGSTs utilize a GSH-dependent Brnsted base mechanism for conversion of the semi-stable LDOX product flavan-3,3,4-triol ( 4 ) or flavan-3-on-4-ol ( 7 ) into flav-2-en-3,4-diol ( 8 -B4), the 4-hydration species of cyanidin ( 8 ) (Extended Data Fig