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Our estimates of ATP consumption rate per NGV unit at 8 Hz firing in both young and aged states align well with literature estimates ( + /K + -ATPase expression in the aged brain are in line with a recent theory of non-canonical control of neuronal energy status ( Furthermore, the model shows that Na + /K + pump ATP use in the astrocyte is comparable to that of the neuron ( Figure 4C ), consistent with recent evidence ( Presentation 1: Supplementary Figure S2 )

High levels of lipid peroxidation produce bioactive aldehydes and ROS igniting inflammation and recurrence of cancer [16, 89], Such by-products may trigger survival promoting pathways to overpower the therapy induced programmed cell death [89]