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Exenatide, an exogenous GLP-1RA, has been shown to enhance hypothalamic connectivity in obese individuals who respond to its anorexigenic effects, while also decreasing food reward-related brain activation

Por ejemplo, a las 40 semanas de tratamiento, los pacientes tratados con retatrutida mostraron una mayor reduccin de HbA1c y peso que aquellos que recibieron placebo

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