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Approximation of the slopes and intercept allowed estimation of apparent K m and V max values from Lineweaver-Burk and Hofstee linear plots were: 27.62 M and 0.66 nmoles ml -1 min -1

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After reviewing five eligible randomized clinical trials involving 497 total participants, the authors found that berberine and silymarin coadministration could lead to an "advantageous improvement in lipid and glucose profile" namely, it could lower total cholesterol, low-density lipoprotein ("bad") cholesterol, and triglycerides while increasing high-density lipoprotein ("good") cholesterol.43 Such impacts are why berberine may be particularly useful to people with type 2 diabetes