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Results of previous studies on topical gel formulation of hydroquinone-loaded SLNs indicated a significantly higher drug deposition within the epidermis layer (46.5% 2.6%) in comparison to the conventional gel of hydroquinone (15.1% 1.8%) (Ghanbarzadeh et al., 2015b)

The study also excluded women with sexual dysfunction secondary to untreated endocrine diseases, those currently undergoing psychotherapy for sexual dysfunction, or those who had recent treatment for depression or psychosis

Safety Note: If you experience shortness of breath, chest pain, or rapid swelling after any IV treatment, this is not a normal side effect

It is difficult to consider some confounders (such as dosage, duration of use, comorbidities, and drug combinations) that may influence the occurrence of gastrointestinal toxicity