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A series of pyrimidine derivatives exemplified by 2 emerged from these hits (Fig

Consistent with this concept, butyrate has been shown to hinder epithelial inflammatory programs via the HDAC-NF-B axis while simultaneously reinforcing the integrity of tight junction proteins, thereby supporting a mechanistic framework in which SCFAs sufficiency couple anti-inflammatory signaling with barrier repair 163

van Venrooij et al., 2014) or AVC in men after adjustment for confounders in the subgroup analysis despite no association in the overall analysis (Morita et al., 2015)