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The pharmacokinetic profiles of these formulations indicate that maximum plasma concentrations are typically attained within 1 to 3 days following SC administration, while steady-state plasma levels are generally achieved after 4 to 5 weeks of once-weekly dosing

These therapies require ongoing monitoring and support

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4 was not observed in enzymatic assay of Cp1A with 12 (ii) and 13 (iii) in the presence of KG, ascorbate, and Fe 2+