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Diabetic peripheral neuropathic pain is a stronger predictor of depression than other diabetic complications and comorbidities

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A commonly studied variant of this gene is Ile105Val polymorphism (rs1695), which involves a single nucleotide change from A to G, resulting in the substitution of isoleucine (Ile) with valine (Val) at codon 105 of the enzyme (Hasni et al., 2016)

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Challenges persist, however, including formulation stability concerns, navigating varying international cosmetic regulations (particularly regarding whitening claims), and increasing competition

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