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Although previous clinical trials suggest that SGLT2 inhibitors have a neutral effect on stroke [6], the HR was 1.18 (95% CI 0.941.48) in those under 65 years of age and 0.83 (95% CI 0.691.00) in those aged 65 years or older ( p interaction = 0.02), suggesting a different efficacy on stroke between older and younger patients

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The relationship between genotype and phenotype in gamma-glutamyl transpeptidase deficiency remains to be established