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Abstract Systemic arterial hypertension is a highly prevalent cardiovascular risk factor that causes significant morbidity and mortality, and is becoming an increasingly common health problem because of the increasing longevity and prevalence of predisposing factors such as sedentary lifestyle, obesity and nutritional habits

By the end of the treatment, the paw thickness of treated animals decreased to less than half of that observed in the untreated control group, and clinical scores were significantly improved, matching the efficacy of subcutaneous melittin administration (107)