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Some users report experiencing anhedonia (a lack of pleasure in previously enjoyable activities), as their brain's normal pathways for reward and satisfaction are disrupted

Supporting this is the notion that long-term or indefinite pharmacotherapy may be necessary to counteract biological adaptations, such as hormonal and metabolic changes, that predispose individuals to weight recidivism - mechanisms consistent with the temporal weight regain trends observed in our review

Semaglutide represents the superior choice for patients seeking maximum weight loss efficacy and who can tolerate gastrointestinal side effects during the initial months of treatment

Rival Eli Lillys tirzepatide, the active ingredient in Mounjaro and Zepbound, showed in a mid-stage trial that up to 74 percent of patients achieved absence of MASH with no worsening of fibrosis