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Differentiating Changes in Glutathione Levels from Cytotoxic Events Using Multiplexed Assays Alisha Truman and Brad Hook Promega Corporation Publication Date: October 2013 Abstract Measuring changes in glutathione levels as a single endpoint may not be sufficiently informative to differentiate a decrease in GSH from a cytotoxic event

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Moreover, an in vivo study using a heterozygous superoxide dismutase (Sod) 2 +/- mouse model and immortalized HC-04 hepatocytes, demonstrated an elevated mitochondrial production of peroxynitrite (ONNO - ) after administration of the analogous prodrug alatrofloxacin 37