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The results showed that the overexpression of ATP6AP1L gene with pcDNA3.1-GST DAF -ATP6AP1L and pcDNA3.1-GST CEAM7 -ATP6AP1L could significantly inhibit the proliferation of K-562 cells compared with the control cells transfected with empty vectors, pcDNA3.1-GST DAF, and pcDNA3.1-GST CEAM7 , respectively

This leads to the dislocation of apical and basolateral transporters (e.g., Na/K-ATPase) resulting in a leaky epithelium

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