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doi: 10.1038/s41591-025-04106-7

They compared weight loss outcomes in people taking chitosan supplements with those of people taking a placebo Results showed that chitosan supplementation slightly reduced body weight and body mass index (BMI) when paired with a calorie-restricted diet and physical activity These results support the findings of a similar, older review, which found that chitosan supplements may be more effective than a placebo as part of a short-term treatment plan for overweight and obesity Both reviews noted improvements in cholesterol levels and blood pressure Reduced cholesterol levels Chitosan may have a greater impact on cholesterol levels than on weight loss

Changes in the subjects functional status (ADL and IADL) were not observed, implying that the effects on ADL and IADL were not significant