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Rationale for metabolic state-driven as an approach for restoring susceptibility in multidrug-resistant pathogens Recent findings demonstrate that the local environment modulates bacterial drug uptake and other aspects of bacterial metabolism 10,11,16,17,18

It was renamed GPER in 2007 by the International Union of Basic and Clinical Pharmacology (IUPHAR) [12], as it contains seven transmembrane domains (TM1-TM7) and is classified as a GPCR (Fig

Any imbalance as observed in diabetes mellitus and other metabolic disorders underscores the critical importance of this regulatory mechanism in clinical practice

These steroidal lactones may possess intrinsic healing properties as antioxidants and anti-inflammatory compounds