If morning injection causes you so much nausea that you skip meals, miss workouts, or dread injection day, the metabolic costs of that stress and disruption far outweigh any circadian benefit
People on any type of weight loss medication lost an average of 8.3kg during treatment, but regained 4.8kg within the first year and were back to their original weight within 1.7 years of stopping the drugs
These findings align with literature proposing multiple pathways through which semaglutide may act, mitigating vascular stiffening, adverse lipid profiles, inflammation, and endothelial dysfunction, alongside effects on glycemic control, insulin resistance, and weight loss [1, 4]
It belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists