This is a long-term, sustainable protocol with ongoing clinician monitoring for optimization
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According to NICE guideline NG28 , GLP-1 receptor agonists like Ozempic may be considered for adults with type 2 diabetes who have specific criteria, including a BMI of 35 kg/m or higher (adjusted for ethnicity) and specific problems associated with high weight, or a BMI lower than 35 kg/m where insulin would have significant occupational implications or weight loss would benefit other significant obesity-related comorbidities
The following shRNA constructs were used (See also Key Resources Table): shGFP, shFOXO4-1: TRCN0000039720, Mature sequence: CCAGCTTCAGTCAGCAGTTAT, shFOXO4-2: TRCN0000039721, Mature sequence: CGTCCACGAAGCAGTTCAAAT, shFOXO4(mouse): TRCN0000071560, Mature sequence: GATCTGGATCTTGATATGTAT, shp53-1: TRCN0000003753, Mature sequence: CGGCGCACAGAGGAAGAGAAT and shp53-2: TRCN0000003754, Mature sequence: TCAGACCTATGGAAACTACTT
