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Weight loss effectiveness Average weight loss expectations: 0.5mg daily: 8-10% over 24 weeks 1.0mg daily: 10-12% over 24 weeks Starting weight ~220 lbs: Lose 22-26 lbs Better than most weight loss medications Similar to GLP-1 agonists Individual variation: Timeline for weight loss: Week 1-2: 2-4 lbs (water weight + appetite suppression ) Week 3-4: 1-2 lbs/week (fat loss beginning) Month 2-3: 1-1.5 lbs/week (steady loss) Month 4-6: 0.5-1 lb/week (slowing, approaching plateau) Month 6-9: 0-0.5 lb/week (maintenance/plateau) Total: 20-30 lbs typical over 6 months Body composition changes: Primarily fat loss (75-80% of loss) Some muscle loss (20-25%) - unavoidable in deficit Better muscle preservation than pure caloric restriction Waist circumference reduction significant Visceral fat preferentially lost See peptides before and after results and how long peptides take to work
Another fantastic option is to include B12 in a subcutaneous fluid injection
Potential Side Effects and Limited Human Data While preclinical studies have not shown significant toxicity at standard doses, the research in humans is still in its early stages
The FUT2 secretor variant p.Trp154Ter influences serum vitamin B 12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation Hum Mol Genet 2017;26:4975-88
