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28 Electrical stimulation has also been shown to enhance mitochondrial biogenesis by activating peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key regulator of energy metabolism and mitochondrial function in regenerating tissues

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the protoporphyrin IX/heme produced may participate in liver injury, and endogenous hydrogen sulfide may elevate serum IL-6 levels