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In vivo evidence corroborates this finding, such that mice with an ApoE4 background display an over 10x higher HSV-1 load in the brain compared to mice with an ApoE3 background, strikingly with viral DNA also being detected in the ovaries, spinal cord and trigeminal ganglia in infected ApoE4 mice (Burgos et al., 2006)

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Comparing two combination regimens (A and B), Regimen B, which employed a 28-day cycle with split-dose oral Vorinostat (days 17 and 1521) and dose-dense, lower-dose ixabepilone (days 2, 9, and 16), demonstrated superior clinical efficacy compared to Regimen A (21-day cycle)

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