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doi: 10.1186/s40249020-00662-x 126 De VitoPIncerpiSPedersenJZLulyPDavisFBDavisPJ

It is simply a boundary

AIM2 suppresses ferroptosis by promoting proteasomal degradation of FOXO3a, a transcriptional activator of ACSL4 a key enzyme that esterifies PUFAs into peroxidation-prone phospholipids essential for ferroptosis execution (259)