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A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

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This delivery method bypasses the gastrointestinal system altogether, so persons in risk groups for vitamin B12 deficiency with gastrointestinal issues may turn to the shot option for a quick means of ensuring their body has sufficient stores of vitamin B12 to effectively function

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