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Nitric oxide (NO), natriuretic peptide type C (NPyC), and eicosanoids are all paracrine chemicals usually secreted by the endothelium

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In addition, hepatic steatosis appears to be a key factor explaining interindividual variation in the daily insulin doses required to achieve good glycemic control in individuals with insulin-treated T2DM (Ryysy et al., 2000[65])