103,104 Consequences include excessive ROS production, progressive lipid accumulation, mitochondrial swelling, cristae disruption, impaired -oxidation, fibrosis, inflammasome activation, and transition from steatosis to MASH
Studies have shown that GLP-1 therapy can significantly reduce the risk of cardiovascular events, including heart attacks and strokes, while also supporting improved kidney function and helping address fatty liver disease
Low doses may not suppress your appetite The starting dosage of semaglutide is very low to reduce the risk of side effects and may not be sufficient to suppress appetite effectively for some people
Subsequent and larger datasets suggest the relative risk may be smaller than this early estimate, especially when compared against agents such as empagliflozin or sitagliptin