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HCPCS code J3398 (Injection, voretigene neparvovec-rzyl, 1 billion vector genomes) is for a gene therapy product indicated for a rare mutation-associated retinal dystrophy

Research indicates that without targeted interventions, lean muscle comprises a meaningful portion of this loss, particularly in the first 36 months of treatment

Providers watch these changes closely because they affect nutrition, hydration, medication tolerance, weight management, and dose decisions

The European Cardiovascular Health Plan Roadmap from the European Alliance was published earlier in 2025 and calls for comprehensive approaches to incorporate the recognition of obesity as a trigger for cardiovascular disease