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[63] These genes include five which as of February, 2024 were classified as inborn errors of immunity genes, i.e., DNASE1L3, TREX1, IFIH1, Tartrate-resistant acid phosphatase and PRKCD [65] [66] [67] and 28 other genes, i.e., NEIL3, TMEM173, ADAR1, NRAS, SAMHD1, SOS1, FASLG, FAS receptor gene, RAG1, RAG2, DNASE1, SHOC2, KRAS, PTPN11, PTEN, BLK, RNASEH2A, RNASEH2B, RNASEH2C, Complement component 1qA, Complement component 1qB, Complement component 1r, Complement component 1s, Complement component 2, Complement component 3, UNC93B1 , and the two complement component 4 genes, C4A and C4B
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Possible involvement of the sympathetic nervous system and endogenous opiates