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A gradual dose-escalation is recommended for liraglutide 3.0 mg, starting with the initial dose of 0.6 mg per day for 1 week, then increasing the dose in weekly increments until the maximum therapeutic dose of 3.0 mg is reached [21]

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The technical innovations of using temperature as an endpoint, combined with forced air cooling and real-time monitoring algorithms has produced a solution that stands alone from more traditional power-based methods